SIBO Treatment Protocol
Complete 8-Week Small Intestinal Bacterial Overgrowth Program
⚠️ IMPORTANT DISCLAIMER
This is a private page exclusively for patients of The Lamkin Clinic.
The information contained on this page is proprietary medical protocol information intended solely for use by patients under the direct care and supervision of Dr. Brian Lamkin and The Lamkin Clinic. This content is NOT for general public use and should NOT be used as general medical advice.
Do not begin this protocol without proper medical supervision. All supplement protocols, dosing schedules, and dietary recommendations must be followed only under the guidance of your healthcare provider. Individual medical conditions, medications, and health status require personalized assessment and monitoring.
If you are not a patient of The Lamkin Clinic, please consult with your own qualified healthcare provider before considering any treatments or protocols mentioned on this page.
🎯 Protocol Overview
8
Week Comprehensive SIBO Treatment
This evidence-based protocol combines biofilm disruption, targeted antimicrobials, gut healing support, and strategic nutrition to effectively treat Small Intestinal Bacterial Overgrowth.
🏥 Weeks 1-2
Biofilm Disruption Phase
- Kirkman Biofilm Defense (1 cap, 2x daily)
- Klaire Labs Interfase Plus (1 cap, 2x daily)
- Begin Low FODMAP Diet
- Digestive Enzymes with meals
- MotilPro (IBS-C only, between meals)
⚔️ Weeks 3-6
Antimicrobial Treatment
- Candibactin AR (2 caps, 2x daily)
- Candibactin BR (2 tabs, 2x daily)
- Continue Low FODMAP
- Digestive Enzymes with meals
- Transition to Paleo (weeks 5-6)
🌱 Weeks 7-8
Restoration Phase
- Seed Probiotic (2 caps daily)
- Low-Glycemic Paleo Diet
- Digestive Enzymes with meals
- Food Reintroduction (one every 3 days)
🩺 Important Note
BPC-157 and MegaMucosa are taken throughout the entire 8-week protocol to support gut healing and minimize treatment reactions.
🔄 Treatment Phases
Weeks 1-2: Biofilm Disruption
Goal: Break down protective bacterial biofilms in the small intestine
- Kirkman Biofilm Defense: 1 capsule twice daily (empty stomach, 30-60 min after meals)
- Klaire Labs Interfase Plus: 1 capsule twice daily (empty stomach, 30-60 min after meals)
- Begin strict Low FODMAP diet
- Start Digestive Enzymes Ultra with meals
- MotilPro for methane-predominant cases (1-3 caps between meals)
Weeks 3-6: Antimicrobial Treatment
Goal: Eliminate bacterial overgrowth with targeted antimicrobials
- Candibactin AR: 2 capsules twice daily (empty stomach, 30-60 min after meals)
- Candibactin BR: 2 tablets twice daily (empty stomach, 30-60 min after meals)
- Continue Low FODMAP diet
- Continue Digestive Enzymes with meals
- Prepare for paleo transition (weeks 5-6)
- Monitor for die-off reactions
Weeks 7-8: Restoration
Goal: Restore healthy microbiome and optimize digestion
- Seed Probiotic: 2 capsules daily (with or without food)
- Transition to Low-Glycemic Paleo
- Careful food reintroduction (one new food every 3 days)
- Continue digestive enzyme support with meals
- Complete gut healing phase
Week 12: Post-Treatment
Goal: Confirm treatment success and establish maintenance
- SIBO breath test recheck
- Assess symptom resolution
- Plan long-term maintenance
- Continue healthy dietary practices
💊 Supplement Protocol
🛡️
Core Gut Healing (Throughout 8-Week Protocol)
BPC-157 Rapid Pro
1 capsule twice daily
Gastric and intestinal healing, reduces inflammation
Order via FullscriptMegaMucosa Powder
1 scoop twice daily
Mucosal barrier support, gut lining repair
Order via Fullscript1-2
Weeks 1-2: Biofilm Disruption
Kirkman Biofilm Defense
1 capsule twice daily
Empty stomach, 30-60 min after meals
Order via FullscriptKlaire Labs Interfase Plus
1 capsule twice daily
Empty stomach, 30-60 min after meals
Order via FullscriptMotilPro (IBS-C only)
1-3 capsules between meals
For methane-predominant cases only
Order via Fullscript3-6
Weeks 3-6: Antimicrobial Treatment
7-8
Weeks 7-8: Restoration
🍽️
Throughout Protocol: Digestive Support
Digestive Enzymes Ultra
1-2 capsules with each meal
Take with first bite of food, continue 6+ weeks
Order via Fullscript🥗 Diet Protocol
🚫 Low FODMAP Diet (Weeks 1-4/6)
Essential for starving bacterial overgrowth and optimizing treatment results
Get Your Professional Meal Plan📍
What is Low FODMAP?
Low FODMAP eliminates fermentable carbohydrates that feed SIBO bacteria:
- Fermentable Oligosaccharides (wheat, onions, garlic)
- Disaccharides (lactose in dairy)
- Monosaccharides (excess fructose)
- And Polyols (sugar alcohols, stone fruits)
Weeks 1-4: Strict Low FODMAP
- Follow Low FODMAP meal plan exactly
- No deviations to ensure bacterial starvation
- Focus on allowed proteins, fats, and vegetables
Weeks 5-6: Paleo Preparation
- Continue Low FODMAP base
- Begin incorporating paleo-approved Low FODMAP foods
- Prepare for transition phase
Weeks 7-8: Low-Glycemic Paleo Transition
- Introduce ONE new food at a time
- Wait 3 days between new foods
- Focus on low-glycemic, nutrient-dense foods
- Continue avoiding high FODMAP initially
📅 Daily Schedule
🌅
Weeks 1-2: Daily Schedule
🌅 Morning (Upon Waking)
- BPC-157 Rapid Pro: 1 capsule
- MegaMucosa Powder: 1 scoop in water
- Wait 30-60 minutes before food
🍽️ Breakfast
- Digestive Enzymes Ultra: 1-2 capsules with first bite
- Low FODMAP meal
📍 Post-Breakfast (30-60 min after)
- Biofilm Defense: 1 capsule (empty stomach)
- Interfase Plus: 1 capsule (empty stomach)
🍽️ Lunch
- Digestive Enzymes Ultra: 1-2 capsules with first bite
- Low FODMAP meal
🍽️ Dinner
- Digestive Enzymes Ultra: 1-2 capsules with first bite
- Low FODMAP meal
📍 Post-Dinner (30-60 min after)
- Biofilm Defense: 1 capsule (empty stomach)
- Interfase Plus: 1 capsule (empty stomach)
🌙 Evening (Before Bed)
- BPC-157 Rapid Pro: 1 capsule
- MegaMucosa Powder: 1 scoop in water
💧 Daily Hydration
- Water goal: 64+ ounces
⚠️ For Methane-Predominant IBS-C Only
MotilPro: Start 1 capsule between meals, increase to max 3 daily as tolerated
⚔️
Weeks 3-6: Daily Schedule
🌅 Morning (Upon Waking)
- BPC-157 Rapid Pro: 1 capsule
- MegaMucosa Powder: 1 scoop in water
- Wait 30-60 minutes before food
🍽️ Breakfast
- Digestive Enzymes Ultra: 1-2 capsules with first bite
- Low FODMAP meal
📍 Post-Breakfast (30-60 min after)
- Candibactin AR: 2 capsules (empty stomach)
- Candibactin BR: 2 tablets (empty stomach)
🍽️ Lunch
- Digestive Enzymes Ultra: 1-2 capsules with first bite
- Low FODMAP meal
🍽️ Dinner
- Digestive Enzymes Ultra: 1-2 capsules with first bite
- Low FODMAP meal
📍 Post-Dinner (30-60 min after)
- Candibactin AR: 2 capsules (empty stomach)
- Candibactin BR: 2 tablets (empty stomach)
🌙 Evening (Before Bed)
- BPC-157 Rapid Pro: 1 capsule
- MegaMucosa Powder: 1 scoop in water
💧 Daily Hydration
- Water goal: 64+ ounces
⚠️ Die-off Symptoms
Common during this phase: fatigue, headache, digestive upset. Stay hydrated and contact provider if severe.
🌱
Weeks 7-8: Daily Schedule
🌅 Morning (Upon Waking)
- BPC-157 Rapid Pro: 1 capsule
- MegaMucosa Powder: 1 scoop in water
- Wait 30-60 minutes before food
🍽️ Breakfast
- Digestive Enzymes Ultra: 1-2 capsules with first bite
- Seed Probiotic: 2 capsules daily (with or without food)
- Low-Glycemic Paleo meal
🍽️ Lunch
- Digestive Enzymes Ultra: 1-2 capsules with first bite
- Low-Glycemic Paleo meal
🍽️ Dinner
- Digestive Enzymes Ultra: 1-2 capsules with first bite
- Low-Glycemic Paleo meal
- Introduce ONE new food every 3 days
🌙 Evening (Before Bed)
- BPC-157 Rapid Pro: 1 capsule
- MegaMucosa Powder: 1 scoop in water
💧 Daily Hydration
- Water goal: 64+ ounces
🎯 Food Reintroduction
Carefully track new foods and any symptoms. Continue Seed Probiotic for full 6 weeks (through week 12).
✅ Progress Tracking
📊 Current Week Progress
Week 1-2 Daily Checklist
Week 3-6 Daily Checklist
Week 7-8 Daily Checklist
📋
Symptom Tracking Tips
- Digestive symptoms: Bloating, gas, abdominal pain, bowel movements
- Energy levels: Fatigue, mental clarity, mood
- Food reactions: Note any foods that cause symptoms
- Die-off symptoms: Headache, flu-like feelings, skin changes
- Improvements: Better digestion, increased energy, mood stability
🩺 When to Contact Your Healthcare Provider
- Severe or persistent digestive upset
- Unmanageable die-off symptoms
- New or worsening symptoms
- Questions about food reintroduction
- Need for protocol adjustments