Functional Medicine Resource
Clinical Articles
Evidence-based articles covering the mechanisms, lab interpretation, and protocol frameworks that guide functional medicine practice at The Lamkin Clinic. Each article reflects how we actually think about and address these questions with patients in real consultations.
37
Clinical Articles
8
Clinical Topics
Evidence-Based
Not Opinion or Theory
25+yr
Clinical Experience
Clinical Articles
Evidence-based functional medicine articles covering the clinical topics most often asked about in consultations: hormone optimization, peptide therapy, gut protocols, lab interpretation, inflammation, and autoimmune mechanisms. Each article is authored and clinically reviewed by Brian Lamkin, DO, and reflects current clinical practice at The Lamkin Clinic.
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Metabolic Articles
Insulin Resistance With Normal Blood SugarFasting insulin and HOMA-IR
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Metabolic Resistance to Weight LossHormones, thyroid, and mitochondria
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Why Do Some People Gain Weight Eating Healthy?Hormonal and metabolic drivers
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Why Does Cortisol Cause Belly Fat?HPA axis and visceral fat
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How Do GLP-1 Medications Cause Weight Loss?Semaglutide and tirzepatide mechanism
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Ferritin Low, Iron High: What It MeansIron panel pattern interpretation
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What Causes Low SDMA on Lab Tests?Protein status and renal context
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Hormone Articles
How Do Doctors Diagnose Hormone Imbalance?Beyond TSH and total testosterone
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What Labs Should Be Checked for Hormone Optimization?Complete panel guide
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What Is the Best Way to Optimize Hormones Naturally?Sleep, training, diet, stress
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What Symptoms Indicate Low Testosterone in Men?Recognition and evaluation
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Is Testosterone Therapy Safe After Prostate Cancer?Saturation model and evidence
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Bioidentical vs Synthetic HormonesMolecular structure and risk
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Gut Articles
Alternatives to Rifaximin for SIBOHerbal and antimicrobial protocols
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What Is the Candibactin Protocol for SIBO?Berberine-based botanical protocol
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How Does Leaky Gut Cause Systemic Inflammation?LPS, TLR4, metabolic endotoxemia
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What Is the Gut-Brain Connection?Vagus, serotonin, and mood
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How Does H. pylori Affect Stomach Acid?Urease and downstream effects
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HypochlorhydriaLow stomach acid
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Inflammatory Gut ConditionsGut-driven systemic inflammation
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Inflammation and Autoimmune Articles
How Does Low Dose Naltrexone Work for Inflammation?TLR4 mechanism and evidence
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Low Dose Naltrexone: Mechanism and ApplicationsMS, fibromyalgia, Crohn's, autoimmune
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How Do Functional Medicine Doctors Treat Autoimmune Disease?Root cause framework
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What Does High TGF-Beta 1 Mean in Chronic Illness?CIRS, fibrosis, autoimmunity
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What Your AA/EPA Ratio Is Telling YouOmega-6 to omega-3 ratio
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What Does a High AA/EPA Ratio Mean?Dietary correction and dosing
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Mast Cell ActivationMCAS mechanism and evaluation
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Neurological Articles
Peptide Therapy Articles
What Are Peptides and How Do They Work?Peptide therapy fundamentals
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Is Peptide Therapy Safe?Evidence and safety profile
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What Peptides Help With Longevity?Epitalon, MOTS-c, Thymosin, GHK-Cu
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What Peptides Improve Mitochondrial Function?SS-31, MOTS-c, Humanin, Epitalon
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What Is MOTS-c Peptide Used For?Mitochondrial metabolic regulator
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Lab Interpretation Articles
Systemic and Complex Articles
How to Use This Library
- Search by topic or keyword using the search bar above
- Filter by clinical topic using the pill buttons
- Browse alphabetically using the A-Z navigation
- Each article explains mechanism, testing, and clinical application
- Written in the same clinical voice as in-person consultations
- Updated as new evidence and clinical experience inform practice
Who These Articles Are For
Patients exploring functional medicine and wanting to understand the clinical thinking behind specific protocols and recommendations. People comparing conventional and functional medicine approaches for a condition they or a family member is facing. Practitioners seeking clinical reference material on functional medicine topics.
These articles are companion reading to the Medical Conditions Library. Where the conditions library maps what a condition is, these articles explain how we think about specific clinical questions inside those conditions.
Why These Articles Exist
The same questions come up in consultations over and over again. What labs should I ask for? Are bioidenticals actually safer than synthetics? Does low dose naltrexone really work? What do I do about SIBO if rifaximin did not help? Instead of explaining the same mechanisms and evidence base in every consultation, I wrote them down. These articles reflect how I actually think about these questions with patients, and how I decide what to do.
Brian Lamkin, DO | Founder, The Lamkin Clinic | Edmond, Oklahoma
Looking for a specific medical condition? The Medical Conditions Library covers 100+ conditions with root-cause mechanisms, key lab markers, and the functional medicine approach to treatment.
Browse Conditions →Need to understand specific biomarkers? The Lab Reference Library covers 110+ markers with functional ranges, clinical interpretation, and optimization strategies.
Explore the Lab Library →Ready to Apply This to Your Own Case?
Schedule a consultation with Dr. Lamkin to discuss your specific situation, review your labs, and build a protocol around what is actually driving your health picture.
Schedule a ConsultationMedical Disclaimer: The content in these articles is provided for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Clinical protocols and interpretations should always be applied in the context of an individual patient's history and presentation by a qualified healthcare provider. Schedule a consultation to discuss your specific situation with Dr. Lamkin.